Systems Biology
Microenvironmental signals control hybrid EMT phenotypes
Contributed by Emanuele GiordanoA Scaffold Simulator to study of cancer cell survival and 3D spatial distribution (SALSA)
Contributed by Marilisa CortesiComputational models of Epithelial to Mesenchymal Transition
Contributed by Marilisa CortesiComputational representation of complex biological processes is becoming an increasingly established approach to complement the experimental analysis and study methods to halt/redirect pathological processes. In this review paper we focus on Epithelial to Mesenchymal transition (EMT), a phenotypic transformation with a pivotal role in cancer progression and ...
Computational model of cell phenotype decision making
Contributed by Marilisa CortesiEpithelial to Mesenchymal transition (EMT) is an exceedingly complex biological process that plays a key role in cancer progression and metastases formation. To unravel this complexity and isolate specific genetic markers important for this transition, we have developed a computational model recapitulating both single cell and population behaviours. The former was ...