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A Scaffold Simulator to study of cancer cell survival and 3D spatial distribution (SALSA)

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3D cell cultures are becoming increasingly common in-vitro approaches to study cell behaviour in more accurate and realistic settings. The experimental study of these systems, however, is complicated by the lack of non-destructive methods for the quantification of relevant properties like cell density and spatial distribution. Computational simulations can be used to address this limitation and provide a framework for testing hypotheses and effectively perform a large number of experiments. To this end, SALSA was developed.

This is a programmable simulator of 3D scaffold-based cell cultures that can be used to determine the temporal evolution of a population behaviour, its interaction with the environment and the effect of changing environmental and experimental conditions.

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Date 2018-11-20
File Size 250.05 KB
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A preliminary version of this work received the “Best Poster Award” at the 4th Barcelona VPH Summer School.

Published in Systems Biology
Marilisa Cortesi

Biomedical engineer graduated magna cum laude at the University of Bologna, Italy, in 2013. In 2017 she was awarded a PhD in Bioengineering from the same institution, with a thesis on computational modelling of complex biological processes and their application to the identification of potential therapeutic targets. More

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