Schematic illustration of a 3D multiphase stem cell-based construct. The scaffold is formed by fibrin hydrogel coating a hyaluronate braided band to embed a) human-bone marrow mesenchimal stem cells (hBMSCs – yellow baby octopuses) and b) poly-lactide-co-glycolide (PLGA) microcarriers (green marbles) loaded with human-growth differentiation factor 5 (hGDF-5) into a multiphase deformable tissue construct able of both biochemical signaling and mechanical strain delivery. The free ends of the hyaluronate band allowed the docking into the holders of a mechanical actuation system for cyclic load transfer
