Computational Cardiology

Cardiac mathematical models have gained a relevant role in the investigation of cellular electrophysiology, and several models have been developed to describe the origins of the human cardiac action potential. Variations of electrolyte concentrations in the extracellular fluid, especially for Ca²⁺ and K⁺, have a crucial role in the action ...

The human induced pluripotent stem cell (hiPSC) technology, discovered in the 2000s, allows us to induce pluripotency and produce stem cells directly from healthy donors and patients. hiPSC-derived cardiomyocytes (hiPSC-CMs) are cardiac cells differentiated from hiPSCs, and they represent a potentially infinite pool of human patient- and disease-specific in vitro ...

The sinoatrial node (SAN) is the normal pacemaker of the mammalian heart. Over several decades, a large amount of data on the ionic mechanisms underlying the spontaneous electrical activity of SAN pacemaker cells has been obtained, mostly in experiments on single cells isolated from rabbit SAN. This allowed the development of comprehensive mathematical models of ...