Thursday, 30 Mar 2023

Synthetic post-transcriptional control of gene expression

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Post-transcriptional regulation allows a faster control of gene expression, which might result relevant in the design of synthetic gene circuits. However, synthetic biologists are warned to give the proper consideration to functional modularity of biological parts and the need for a case-to-case characterization of their function, raising concern about the use of a overconfident bottom-up approach in synthetic biology and supporting the idea that emerging properties are a rule in nature that we must consider in the application of engineering principles to biology.


Ceroni F. et al.  A synthetic post-transcriptional controller to explore the modular design of gene circuits. ACS Synthetic Biology ISSN 2161-5063 (2012) 1(5):163-171. DOI: 10.1021/sb200021s


Gene circuit mc

Published in Synthetic Biology
Emanuele Giordano

Emanuele D. Giordano is an Italian Biomedical Scientist, affiliated with the Alma Mater Studiorum – Università di Bologna. He earned his MD degree (with Honours) at the Università di Roma “La Sapienza” in 1985. He received his PhD (1997) degree in Biochemistry at the Alma Mater Studiorum – Università di Bologna. More