Multidisciplinary approaches prove to be helpful to investigate microenvironmental signals driving cancer cell molecular phenotype. Epithelial to Mesenchymal transition (EMT) has a pivotal role in cancer progression and metastasis formation. Coupling in silico and in vitro analyses, this manuscript gains an insight in the signal transduction cascades driven by a stiff extracellular matrix to trigger a full mesenchymal phenotype out of a heterogeneous cancer cell population.
The full paper, by Gianluca Selvaggio et al., is available at https://cancerres.aacrjournals.org/content/early/2020/03/26/0008-5472.CAN-19-3147
