Friday, 26 Feb 2021

Microenvironmental signals control hybrid EMT phenotypes

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Multidisciplinary approaches prove to be helpful to investigate microenvironmental signals driving cancer cell molecular phenotype. Epithelial to Mesenchymal transition (EMT) has a pivotal role in cancer progression and metastasis formation. Coupling in silico and in vitro analyses, this manuscript gains an insight in the signal transduction cascades driven by a stiff extracellular matrix to trigger a full mesenchymal phenotype out of a heterogeneous cancer cell population.

MCBeng EMT and MET while metastasis

The full paper, by Gianluca Selvaggio et al., is available at https://cancerres.aacrjournals.org/content/early/2020/03/26/0008-5472.CAN-19-3147

Published in Systems Biology
Emanuele Giordano

Emanuele D. Giordano is an Italian Biomedical Scientist, affiliated with the Alma Mater Studiorum – Università di Bologna. He earned his MD degree (with Honours) at the Università di Roma “La Sapienza” in 1985. He received his PhD (1997) degree in Biochemistry at the Alma Mater Studiorum – Università di Bologna. More