3D cell cultures are becoming increasingly common in-vitro approaches to study cell behaviour in more accurate and realistic settings. The experimental study of these systems, however, is complicated by the lack of non-destructive methods for the quantification of relevant properties like cell density and spatial distribution. Computational simulations can be used to address this limitation and provide a framework for testing hypotheses and effectively perform a large number of experiments. To this end, SALSA was developed.
This is a programmable simulator of 3D scaffold-based cell cultures that can be used to determine the temporal evolution of a population behaviour, its interaction with the environment and the effect of changing environmental and experimental conditions.
Read the full text at: https://www.nature.com/articles/s41598-020-69862-7
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A preliminary version of this work received the “Best Poster Award” at the 4th Barcelona VPH Summer School.
